This work looked at effect of workplace stress on employee performance among female workers in Nigerian Banks with special reference to United Bank for Africa and First Bank Nigeria plc all in Makurdi Metropolis. The framework provided an indication of how we managed stress and its effect on employee performance. The objective of this study is to determine the effect of acute stress on the performance of female workers in Nigeria Banks, determine the effect of Episodic stress on the performance of female workers in Nigeria Banks and examine the effects of chronic stress on the performance of female workers in Nigeria Banks. A survey research design was adopted for this study and the study was conducted using the sample size of ninety-nine (99) selected among the female Bankers of the study area. The method of data collection for this study are documentary studies and data collection through carefully implemented questionnaire. Results of the field work were presented in tables and analysed with multiple regression analysis with the help of SPSS. Cronbach’s alpha statistical tool was adopted to test the validity as well as reliability of the data. The findings reveal that stress is considered as a major determinant in the performance of female workers in the Nigeria Banks. And also, that there is significant relationship between workplace stress and employee’s performance. Recommendations were provided based on the result of the findings that problem focused coping is aimed at reducing the demands of the stressful situation or expanding resources to deal with it.