This study investigates the environmental and health impacts of air pollution in Port Harcourt, Nigeria, using a cross-sectional research design. The concentrations of major air pollutants, including PM2.5, PM10, CO2, CO, black soot, SO2, NOX, and VOC, were measured using the Met-One GT-321 Hand-held Particle Counter and Extech Digital Hygro-thermo-Anemometer 45170 for meteorological data. The results indicate that air pollution in Port Harcourt is a significant environmental issue, with notable health impacts such as eye irritation, bronchial and respiratory disorders, and metal corrosion. Among the pollutants, PM2.5 was identified as the primary concern. The Air Quality Index (AQI) was generally categorized as unhealthy (100-221) during morning hours and moderate (60-98) in the evening. The pollution levels were higher during the dry season compared to the rainy season. Areas like Total Village and Trans-Amadi I.A. were found to be the most polluted, with AQI levels ranging from 80 and above, while Onne was identified as the least polluted area with AQI values between 24 and 45, categorized as good. The study also found that wind directions and speeds varied significantly during the day and night, influencing the dispersion of pollutants. For instance, the wind in the morning shifted to a lower speed and direction at night, leading to discomfort in the evenings due to still air conditions. Based on these findings, the paper recommends strict monitoring and regulation of air pollution-related activities to mitigate the adverse health effects in the region.