This study investigates the relationship between environmental conditions and the quality of life of residents in Warri South-West, Delta State, Nigeria. A multi-stage random and systematic sampling procedure was utilized, and sixteen communities were selected for the administration of questionnaires. These questionnaires aimed to gather data on the variations in residential environmental conditions and quality of life. Additionally, interviews were conducted with local chiefs from three wards to provide insights into the comparative quality of life in the area. Data analysis involved simple descriptive statistics, cross-tabulation of variables, and testing hypotheses using analysis of variance and multiple regression. The findings revealed a significant relationship between environmental conditions and residents' quality of life, with socio-economic factors such as educational attainment, household size, and income influencing these conditions. However, no relationship was found with age and marital status. The study highlighted that the poor environmental setting is a critical barrier to sustainable housing, exacerbated by frequent environmental disasters. The study recommends increased public awareness, particularly during the state’s environmental sanitation exercises, to encourage better waste management practices, such as discouraging waste disposal in drains and on roadsides