Objective: Diagnose multi-level barriers inhibiting COVID-19 vaccination among Ghanaian urban professionals using a socio-ecological model to inform targeted intervention design. Method: Analysis of peer-reviewed studies, surveys, policy and legal environments across individual, interpersonal, organizational, community and societal lenses. Results & Conclusion: Individual knowledge gaps, interpersonal hesitancy contagion, workplace promotion deficiencies, community influencer resistance and fractured policy regimes collectively sustain vaccine equity gaps among medical, education and corporate professionals demanding tailored solutions acting across linked social-institutional layers simultaneously. Recommendations: Right-size risk communication, leverage professional networks, strengthen occupational policy, transparency and localized community partnership-based drives to uplift coverage among frontline worker cohorts. Novelty & Significance: Granular diagnosis of impediments, legal-institutional contexts and solution pathways across socio-ecological spectrum surrounding Ghanaian urban professionals provides original occupational health contributions transferrable regionally.