Amidst vaccine safety hesitancy risks, this analysis applies CREAC method to interpret Ghana’s Food and Drugs Law 1992 (PNDCL 305B) establishing regulation alongside Public Health Act 2012 (Act 851) enabling compulsion, evaluating policy levers balancing access assurance and outbreak response efficacy with dissent and rights protections. Key amendments and guidance recommended affirm nuanced applications upholding exemption and exclusion fairness amidst necessity, minimizing restrictions through transparent and accountable procedures. Significantly, codifying posterity considerations builds trust in oversight systems with Phase IV post-market surveillance while proactive rights jurisprudence presses judicious state action – fostering adoption not resistance.