Background: Hyperglycemia is a common postoperative complication that has been associated with poor outcomes in critically ill patients, including impaired wound healing and increased morbidity. Postoperative hyperglycemia is a result of a hyper-metabolic stress response triggered by surgery, which leads to increased glucose production and insulin resistance. This stress response is influenced by various factors, such as the type and duration of the surgery, the anesthesia used, and patient-specific variables like age, gender, and pre-existing conditions such as diabetes. Methods: This study involved 200 patients (168 females and 32 males), aged between less than 1 year and 80 years, who underwent various types of surgeries. These patients received either general anesthesia or spinal anesthesia. Capillary blood samples were collected at the time of admission for surgery and on the first postoperative day. Blood glucose levels were measured using the HMG method to analyze the impact of surgery and anesthesia on postoperative glucose levels. Results: The study population had a mean age of 31.51 years, with the majority being female (84%) and non-diabetic (96.5%). The most common procedure performed was cesarean section (68%), and spinal anesthesia was administered in 72.5% of cases. The mean postoperative glucose level was 123.28 mg/dL (SD = 30.765), with minor variations in glucose levels observed across different types of surgery and anesthesia. No statistically significant difference was found in postoperative glucose levels based on surgery type, surgery duration, or anesthesia type (p > 0.05). Conclusion: This study highlights the complex relationship between surgical stress and postoperative glucose metabolism. While factors such as surgery type, duration, and anesthesia did not significantly affect postoperative glucose levels in this cohort, the results underscore the importance of vigilant monitoring and management of glucose levels in surgical patients. Further research with larger sample sizes and more comprehensive perioperative glucose management protocols is needed to optimize patient care and improve surgical outcomes