Prostate cancer (PCa) remains one of the most prevalent cancers worldwide, contributing significantly to male cancer-related mortality. Early detection through screening is crucial for improving prognosis and reducing mortality rates, particularly among high-risk populations such as African American men. Despite the availability of screening methods like prostate-specific antigen (PSA) testing, digital rectal exams (DRE), and imaging techniques, uptake of these screenings among African American men remains disproportionately low. This study systematically reviews literature on the multifaceted factors influencing prostate cancer screening participation within this group. It identifies key individual-level determinants, including knowledge, awareness, psychological barriers, and cultural and socioeconomic factors, which influence screening decisions. The study also explores how systemic and institutional factors contribute to the disparities in screening uptake. It underscores the need for targeted interventions that address these factors, with an emphasis on culturally sensitive approaches that consider the unique challenges faced by African American men. By synthesizing evidence-based insights, this study proposes comprehensive strategies aimed at improving prostate cancer screening rates and reducing health disparities, ultimately leading to better health outcomes for African American men