The rapid development and progress of urbanization has also driven the further development of transportation and construction industry on a certain level. If we really want to ensure the overall and effective improvement of the longitudinal pier height difference for the corresponding seismic performance of the bridge itself, we should also continuously strengthen the detailed grasp of the height difference in the construction process, so as to reduce the appearance of some obvious constraints. It is also under such basic conditions that this paper carries out a more in-depth study and discussion from three perspectives: a brief overview of height difference, precautions for bridge seismic response work, and research on the influence of longitudinal pier height difference on bridge seismic response, which also ensures the daily travel safety of the people to a great extent.