UpToDate fungal infections are linked to cancer development in different part of human body. This association frequently seen in individuals has immune system issues and elderly people. Microbial infections in charge of more than 2 million of cancer cases. Invasive fungal infection sustains cancer growth rate and needed to scrutinized. The commonest genus and species of fungi involved are Candida albicans, Candida tropicalis, Aspergillus flavus, Fusarium proliferatum and others. Oral candidiasis consumes the vast majority of oral fungal infections specially when combined with receiving a cancer therapy. This review deals with risk of oral candida and their role in progressing of oral cancer beside co-factors like health status, alcohol, smoking and immune deficiency