In the field of bone tissue engineering, ensuring adequate blood supply post-transplantation is critical for successful outcomes. Recent advances in microRNAs (miRNAs) provide new opportunities for improving bone regeneration by precisely regulating target genes and promoting angiogenesis. miRNAs, known for their sequence conservation, temporal expression patterns, and tissue specificity, play a pivotal role in angiogenic processes. Addressing the challenge of insufficient blood supply is essential to bridge the gap between laboratory research and clinical application in bone tissue engineering. This article explores the potential of miRNAs as a tool to enhance angiogenesis in bone regeneration therapy.