Health care workers’ attitude is one of the factors that can either motivate or discourage patients from adhering well to treatment. Swaziland is one of the countries that is highly burden with TB/HIV co infected diseases and all effort is being put in place for its eradication by 1935. This projection is according to WHO summit in the year 2015. Training and motivation are the major factors that affect health care workers attitude towards TB patients within a health care set up. The aim of the study is to know the effect of health care workers’ attitude on TB patients in the Hhohho region of Swaziland. A cross sectional study using survey method through questionnaire was used to derive a valid and reliable result. This study found out that basic information on either susceptible TB or MDR TB plays a prominent role on patient’s treatment. Also, patient’s appreciation does motivate nurses to perform better when administering treatment. Lastly, it is noted that nurses’ mood sometimes affects administering of treatment on TB patient