The study was aimed to determine the determinants and features of the poverty and inequalities in Africa. The multiple regression models was use to analysed the data from 31 African countries. The macro factors are used to examine the influences of macro factors on poverty and inequalities. The study finds that, the key determinants of the poverty and inequalities are GNI per capita, government effectiveness, ICT use, gender inequalities, FDI Net flows, political stability, ease to pay taxes and easiness to get credit in a country. The study recommends the reduction of poverty should be weighted on increases the use of ICT, increases the effectiveness of implementation of MDG3, and the restructuring of the microcredit policy and outreaching the services to the rural and poor people, and government effectiveness.