Research Article Open Access Double-Blind Peer Review

HORMONAL THERAPY FOR PREMENOPAUSAL WOMEN WITH EARLY-STAGE HORMONE RECEPTOR-POSITIVE BREAST CANCER: A CRITICAL REVIEW

Dr. Ahmed Mustafa Al-Dulaimi
Published 21 February 2025
Vol. 11, No. 4 (2023)
pp. 47-55
CC BY 4.0
  1. 1
    Dr. Ahmed Mustafa Al-Dulaimi
    Consultant Surgeon, Department of Surgery, College of Medicine, University of Babylon, Iraq
    IQ

Aim: To highlight Tamoxifen and ovarian suppression as effective adjuvant approaches for premenopausal steroid receptor-positive breast cancer. In addition to encourage surgeons toward breast-conserving surgery with this effective adjuvant approaches. Patients and Methods: Premenopausal women with early stages, steroid hormone receptor– positive breast cancer, 100 selected patients, for retrospective study were randomly assigned to six or eight cycles of chemotherapy. Followed by two years of monthly Goserelin, and daily Tamoxifen for five years. The primary endpoints were time to recurrence (TTR) for Tamoxifen alone therapy versus combined Tamoxifen and Goserelin therapy. Results: With two year follow-up, the combination of Tamoxifen and Goserelin show improved time to recurrence (TTR). Conclusion: Combination of Tamoxifen and Goserelin improves outcome for premenopausal stage1, II and IIIA, hormone receptor-positive breast cancer

JournalOncology Journal
ISSN3065-0356
Volume / IssueVol. 11, No. 4 (2023)
Pages47-55
Published21 February 2025
Access Open Access
LicenseCC BY 4.0 — reuse with attribution
PublisherKeith Publications
Al-Dulaimi, D. (2025). HORMONAL THERAPY FOR PREMENOPAUSAL WOMEN WITH EARLY-STAGE HORMONE RECEPTOR-POSITIVE BREAST CANCER: A CRITICAL REVIEW. Oncology Journal, Vol. 11 No. 4, pp. 47-55

 Submit Your Research to Oncology Journal

We invite original research articles, review papers, and case studies. Benefit from rigorous double-blind peer review, rapid decision within 4–8 weeks, DOI for every article, and worldwide open-access distribution.