This study investigated the predictors to utilization of preventive measures of prostate cancer among men attending health facilities in Rivers South-East senatorial district, Rivers State. Seven objectives, seven research questions and six hypotheses were stated to guide the study. Literature was reviewed under conceptual framework, theoretical framework and empirical review. A descriptive cross-sectional design was adopted with a population which consisted of 134,311 men from 50 years and above in Rivers South East Senatorial district. A sample size of 500 was selected using the multi-staged sampling procedure. The instrument for data collection was semi structured questionnaire titled ‘Questionnaire on Predictors of Utilization of Prostate cancer preventive measures (QPUPCPM)’ with a reliability coefficient of 0.82. Analysis was done with the aid of the Statistical Product for Service Solution (IBM SPSS 23) using mean, standard deviation and linear regression at 0.05 alpha level. The finding of the study showed that the level of utilization of prostate cancer preventive measures among men attending health facilities in Rivers South East Senatorial District was low (1.86±0.85). The result of the study indicated that the utilization of prostate cancer preventive measures was predicted by the availability of screening facilities (r = 0.97, R2 = 0.972, p<0.05); affordability of screening services (r = 0.94, R2 = 0.891, p<0.05); educational attainment (r = 0.94, R2 = 0.896, p<0.05); knowledge of benefit of early diagnosis (r = 0.95, R2 = 0.920, p<0.05); religious belief (r = 0.91, R2 = 0.841, p<0.05); and support from partners (r = 0.94, R2 = 0.894, p<0.05). It was concluded that, utilization of preventive measures of prostate cancer among men was predicted by several factors as mention above. The Ministry of Health should make effort to promote prostate cancer prevention among men by establishing well organized prostate cancer screening programme at strategic points in the State.