Non-communicable diseases (NCDs) pose a significant global health challenge, contributing to a substantial portion of annual deaths. This study addresses a critical gap in the literature by examining the knowledge levels of NCDs within the Afigya-Kwabre South District in the Ashanti region of Ghana. Understanding community knowledge of NCDs is vital for developing effective public health interventions to prevent these diseases and reduce their impact on lifestyle. The study will provide valuable insights into the current state of awareness and perception of NCDs in a rural setting, shedding light on areas where educational initiatives can be improved.