Non-Communicable Diseases (NCDs), including cardiovascular diseases, cancers, chronic respiratory conditions, and diabetes, are leading causes of premature mortality worldwide, with a disproportionate impact in developing countries such as Nigeria. Academic staff in tertiary institutions in Ondo State face a growing health challenge, manifested in increased absenteeism, prolonged sick leave, and lifestyle-related health complications. The sedentary nature of academic work—characterized by extended periods of sitting during lectures, research, and administrative duties—further exacerbates the risk of developing NCDs. While general health awareness exists among this population, gaps remain in specific knowledge of NCDs, their risk factors, symptoms, and complications. Misconceptions, such as the belief that NCDs affect only certain social groups, undermine the adoption of preventive health behaviors. This study explores the health behaviors and self-efficacy of academic staff in managing NCD risks, highlighting the need for targeted interventions that promote lifestyle modifications, enhance disease awareness, and strengthen self-management capacities. Findings from this study are expected to inform health promotion strategies tailored for academic personnel, ultimately reducing NCD-related morbidity and improving overall workforce productivity.