The field of humanitarian medicine is growing rapidly, and nurses play a vital role in global health initiatives. Short Term Medical Missions (STMMs) are becoming increasingly popular within this context, with numerous teams and programs participating in providing medical services to low and middle-income countries. While these missions are driven by good intentions, they are not without their challenges and potential negative consequences. Nurses, with their unique skill set, are a valuable asset in addressing health inequalities and improving healthcare delivery, particularly during STMMs. This article explores the evolving role of nurses in humanitarian medicine and highlights the importance of thoughtful consideration and ethical practices in STMMs to ensure their effectiveness.