This study focused on the influence of international public sector accounting standards (IPSAS) on financial reporting quality of public health institution in Nigeria. The research design adopted for the study was survey research design was chosen because it is effective in gathering primary data using a well-designed instrument that would aid statistical analysis. The population was finite in nature and relatively small; hence, it became imperative to use the entire population of one hundred and fourteen (114) as samples. The questionnaire was designed to gather data on the perceptions of relevant and knowledgeable staff on the influence of international public sector accounting standards (IPSAS) on financial reporting quality of the selected Federal Health Institutions in Nigeria. The questions were carefully worded and focused on the sets of statement to elicit relevant information regarding the thrust of the study. Analysis of Variance and ordinary least square were used to inferentially analyze the data obtained, while frequency tables, averages, and standard deviation were utilized to characterize the features of the data. The findings of the study were that the R Square of 93.4% suggests a very strong model which revealed that the total variation in the financial reporting quality of the selected FHIs was attributed to IPSAS, represented by accruals and aggregation and materiality of Financial Statements. This study recommended that Federal Health Institutions should increase their disclosures in their financial statements by fully complying with IPSAS, as doing this will further improve the decision-usefulness and comparability of their financial reports.