Abstract

<p>Bone tissue engineering aims to develop strategies to promote bone regeneration in cases of injury or disease. One critical factor <br>for successful bone regeneration is efficient vascularization, as it ensures the supply of essential nutrients to support new bone <br>growth. The intricate relationship between angiogenesis (blood vessel formation) and osteogenesis (bone formation) is crucial<br>for the healing of bone defects. This review summarizes recent research on signaling molecules that play a significant role in <br>promoting angiogenesis within bone tissue engineering. By understanding these signaling pathways, researchers can develop <br>innovative approaches to enhance vascularization and ultimately improve the outcome of bone tissue engineering strategies.</p>