Abstract

<p>Intervertebral disc degenerative diseases have been increasingly explored, focusing on the balance of synthesis and catabolism, <br>extracellular matrix, growth factors, and inflammatory factors as the underlying causes. Researchers have sought to address <br>these conditions through molecular therapy, cell therapy, and gene therapy. While molecular therapy targets the regulation of<br>growth factors and reduction of inflammatory factors, cell therapy involves the transplantation of exogenous cells and <br>autologous nucleus pulposus cells. Gene therapy, on the other hand, is focused on the inhibition of inflammatory factors through <br>exogenous growth factors. However, these biotherapies face challenges due to the incomplete understanding of disc <br>degeneration's pathogenesis. Advancements in biological therapy depend on further elucidating the mechanisms of <br>intervertebral disc degeneration, making it a crucial area for research exploration.<br>In this study, we conduct a bibliometric analysis to assess the current status and trends in intervertebral disc degeneration<br>research, with a particular focus on nucleus pulposus cells and inflammatory responses. The aim is to identify promising <br>keywords and research directions in this field.</p>